Hyaluronic acid is a high molecular weight polysaccharide with D-glucuronic acid and N-acetyl-glucosamine as repeating structure unit.Because of the action of hydrogen bond between the monosaccharide in HA linear axle,HA molecular forms a rigid screw column structure in space.Strong hydrophilic properties exist due to the large amount of hydroxyl groups. Furthermore,HA has a special water binding function and binds its water very strongly,so that it has strong water retention. Theoretically its binding water capacity is up to 500 ml/g as an ideal natural moisturizing factor.
HA is also one important component of the skin.It can prevent skin from aging and improve the appearance and tactile sensation of skin.
A part of low molecular weight HA can penetrate into dermal layer to control the mid-metabolism,and make the skin moist, smooth and elastic.Therefore the cosmetic functions of HA are its resistance against skin wrinkles and its general health protection.HA is not only a good skin moisturizer,but also promotes cell's metabolism of skin.So HA stands for bio-mimetic cosmetics.The content of hyaluronic acid in body will decrease as they are aging,oral hyaluronic acid supplementation can supplement HA in body and improve skin conditions,moisturizing skin from the inside out,smoothing out wrinkles during cell metabolism.Oral hyaluronic acid Supplementation is very popular in Japan,USA and other western countries.
Hyaluronic acid is a natural part of the human body why it is highly suitable for many applications within the field of medicine and related aids.It is used in ophthalmology,orthopedics and cosmetic surgery.With the researching and development of application in medicine area,hyaluronic acid's application as HA-supplementation and medical treatment material will be one major stream in health care Industry.
Hayluronic acid for cosmetic industry
Hyaluronic acid exists naturally in all living organisms and is a universal
component of the spaces between the cells of body tissues(extracellular
space)and eye vitreous body.It has special function:
·Moisturizing effect and Nutritional ingredient
·Thickening,Lubricating and membrane-forming
·Sun-screening and restoration of skin trauma
Recommended:0.05%～0.5%
HA is widely found in the extracellular matrix of animal tissues and vitreous humor.Its main biological role is water retention and lubrication.
HA is produced in highest level during embryonic period of life,gradually decreases after birth.HA content is different among the crowd of the same age.For example,HA content of the premature senility patient is obviously reduced.
Topical usage of HA can play the action of water retention and lubrication on the surface of the skin.Its limit is obvious.However,oral HA can increase endogenetic HA by digesting and absorbing and make skin moist, bright,springy.
HA also plays important role of water retention and lubrication in other tissues and organs,such as joint cavity,blood vessel,heart and brain. Decrease of HA will lead to arthritis,arteriosclerosis,pulse disorder and brain atrophy.Oral HA can restore the normal content of HA,delay apolexis and make the body energic.
At present,HA is widely applied in health and beauty food in America and Japan.It is great welcomed by the consumers.Oral HA shows remarkable effectiveness on moisturizing skin from the inside out, smoothing out wrinkles in the process and make skin moist,bright, springy.
Natural “shock absorber”:
Relieving inflammation and ache,hyaluronic Acid is an important constituent of joint fluid where it serves as a lubricant and supports joint flexibility and mobility.It acts as a natural barrier to protect cells from microbe or virus.
sodium hyaluronate powder for cosmetic industry
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Cosmetic grade sodium hyaluronate
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项 目 |
Item |
指标 |
standard |
|
外观 |
Appearance |
白色粉末或颗粒状 |
white powder or granular |
|
葡萄糖醛酸 |
D-glucuronic acid |
≥44.0% |
≥44.0% |
|
蛋白质 |
Protein |
≤0.1% |
≤0.1% |
|
干燥失重 |
Loss on drying |
≤10.0% |
≤10.0% |
|
澄清度(0.1%水溶液) |
Transparency(0.1%solution) |
≥99.0% |
≥99.0% |
|
PH值(0.1%水溶液) |
PH(0.1%solution) |
5.5～7.5 |
5.5～7.5 |
|
重金属(以铅计) |
Heavy metal |
≤2×10-⁵ g/g |
≤2×10-⁵g/g |
|
细菌总数 |
Total aerobic plate count |
≤100个/g |
≤100 CFU/g |
|
粪大肠杆菌 |
Escherichia Coil |
不得检出 |
Absent |
|
绿浓杆菌 |
Salmonella |
不得检出 |
Absent |
|
金黄色葡萄球菌 |
Staphylococcus Aureus |
不得检出 |
Absent |
1% sodium hyaluronate solution for cosmetic industry
|
项 目 |
Item |
指标
|
Standard |
|
葡萄糖醛酸 |
D-glucuronic acid |
≥0.44mg/ml |
≥0.44 mg/ml |
|
动力粘度(mPa.s) |
kinematic viscosity(mPa.s) |
实测值 |
Actual value |
|
蛋白质 |
Protein |
≤0.002% |
≤0.002% |
|
澄清度(0.1%水溶液) |
Transparency(0.1%solution) |
≥99.0% |
≥99.0% |
|
PH值(0.1%水溶液) |
pH (0.1%solution) |
5.5～7.5 |
5.5～7.5 |
|
重金属(以铅计) |
Heavy metal |
≤2×10-⁵ g/g |
≤2×10⁻⁵ g/g |
|
细菌总数 |
Total aerobic plate count |
≤100个/g |
100 CFU/g |
sodium hyaluronate powder for food industry
项 目
Item
指标
Standard
外观
Appearance
白色粉末或颗粒状
White powder or granular
葡萄糖醛酸
D-glucuronic acid
≥44.0%
≥44.0%
蛋白质
Protein
≤0.1%
≤0.1%
干燥失重
Loss on drying
≤10.0%
≤10.0%
灼烧残渣
Residue on ignition
≤15.0%
≤15.0%
澄清度(0.1%水溶液)
Transparency(0.1%solution)
≥99.0%
≥99.0%
PH值(0.1%水溶液)
pH(0.1%solution)
5.5～7.5
5.5～7.5
重金属(以铅计)
Heavy metal
≤2×10-⁵ g/g
≤2×10⁻⁵ g/g
砷
Arsenic
≤02×10⁵g/g
≤0.2×10-⁵ g/g
细菌总数
Total aerobic plate count
≤100个/g
≤100 CFU/g
霉菌总数
mould
≤100个/g
≤100 CFU/g
粪大肠杆菌
Escherichia Coil
不得检出
Absent
沙门氏菌
Salmonella
不得检出
Absent
金黄色葡萄球菌
Staphylococcus Aureus
不得检出
Absent
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